https://cursodspace.dgru.unam.mx/handle/123456789/10001 Fri, 10 Apr 2026 22:56:48 GMT 2026-04-10T22:56:48Z https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/A111 Title: The receptor binding domain of SARS-CoV-2 spike protein is the result of an ancestral recombination between the bat-CoV RaTG13 and the pangolin-CoV MP789 Authors: Sandner Miranda, Luisa; Delgado Sapien, Gabriela; Cravioto Quintana, Alejandro Rafael; Morales Espinosa, María Del Rosario Abstract: In December 2019 a novel coronavirus (SARS-CoV-2) that is causing the current COVID-19 pandemic was identified in Wuhan, China. Many questions have been raised about its origin and adaptation to humans. In the present work we performed a genetic analysis of the Spike glycoprotein (S) of SARS-CoV-2 and other related coronaviruses (CoVs) isolated from different hosts in order to trace the evolutionary history of this protein and the adaptation of SARS-CoV-2 to humans. Wed, 01 Jan 2020 00:00:00 GMT https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/A111 2020-01-01T00:00:00Z https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/A110 Title: Differential adhesion and fibrinolytic activity of mesenchymal stem cells from human bone marrow, placenta, and Wharton's jelly cultured in a fibrin hydrogel. Authors: Ambriz Peña, Xochitl::cvu::267835; Montesinos Montesinos, Juan José::cvu::121752; Hernández Tellez, Beatríz::cvu::898850; Piñón Zárate, Gabriela::cvu::175653; Herrera Enríquez, Miguel Angel::ca::297450; Hernández Estevez, Erika Aydé::cvu::545277; Ambrosio Hernández, Javier Rolando::cvu::120362 Abstract: Mesenchymal stem cells isolated from different tissues should share associated markers and the capability to differentiate to mesodermal lineages. However, their behavior varies in specific microenvironments. Herein, adhesion and fibrinolytic activity of mesenchymal stem cells from placenta, bone marrow, and Wharton's jelly were evaluated in fibrin hydrogels prepared with nonpurified blood plasma and compared with two-dimensional cultures. Despite the source, mesenchymal stem cells adhered through focal adhesions positive for vinculin and integrin ?V in two dimensions, while focal adhesions could not be detected in fibrin hydrogels. Moreover, some cells could not spread and stay rounded. The proportions of elongated and round phenotypes varied, with placenta mesenchymal stem cells having the lowest percentage of elongated cells (~10%). Mesenchymal stem cells degraded fibrin at distinct rates, and placenta mesenchymal stem cells had the strongest fibrinolytic activity, which was achieved principally through the plasminogen-plasmin axis. These findings might have clinical implications in tissue engineering and wound healing therapy. Tue, 01 Jan 2019 00:00:00 GMT https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/A110 2019-01-01T00:00:00Z https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/DPCOVID9 Title: ¿Cómo desinfectar superficies con dilución de cloro? Authors: Comisión Especial COVID19, Facultad de Medicina::rol::Autor Fri, 01 Jan 20200326 00:00:00 GMT https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/DPCOVID9 20200326-01-01T00:00:00Z https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/DPCOVID7 Title: Alejados nos cuidamos Authors: Comisión Especial COVID19, Facultad de Medicina::rol::Autor Wed, 01 Jan 20200313 00:00:00 GMT https://cursodspace.dgru.unam.mx/handle/FACMED_UNAM/DPCOVID7 20200313-01-01T00:00:00Z